Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms

Brazilian Journal of Medical and Biological Research

R. Otero¹  V. Núñez¹  J.m. Gutiérrez¹  A. Robles¹  R. Estrada¹  R.g. Osorio¹  G. Del-valle¹  R. Valderrama¹  C.a. Giraldo¹ 

关键词: Bothrops atrox;    snake venom;    antivenom;    neutralization;    Antioquia;    Chocó;   

DOI  :  10.1590/S0100-879X1997000300011

来源: SciELO

【 摘 要 】

Three horse-derived antivenoms were tested for their ability to neutralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxic activities induced by the venom of Bothrops atrox from Antioquia and Chocó (Colombia). The following antivenoms were used: a) polyvalent (crotaline) antivenom produced by Instituto Clodomiro Picado (Costa Rica), b) monovalent antibothropic antivenom produced by Instituto Nacional de Salud-INS (Bogotá), and c) a new monovalent anti-B. atrox antivenom produced with the venom of B. atrox from Antioquia and Chocó. The three antivenoms neutralized all toxic activities tested albeit with different potencies. The new monovalent anti-B. atrox antivenom showed the highest neutralizing ability against edema-forming and defibrinating effects of B. atrox venom (41 ± 2 and 100 ± 32 µl antivenom/mg venom, respectively), suggesting that it should be useful in the treatment of B. atrox envenomation in Antioquia and Chocó

【 授权许可】

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