Atividade antimicrobiana do oleorresina de copaíba (Copaifera reticulata) frente a Staphylococcus coagulase positiva isolados de casos de otite em cães

Pesquisa Veterinária Brasileira

Rosangela E. Ziech²  Luana D. Farias²  Cláudia Balzan²  Magnos F. Ziech¹  Berta M. Heinzmann¹  Osmar A. Lameira¹  Agueda C. De Vargas² 

[1] ,Universidade Federal de Santa Maria Centro de Ciências Rurais Departamento de Medicina Veterinária PreventivaSanta Maria RS ,Brasil

关键词: Phytotherapy;    copaiba oil;    Copaifera reticulata;    Staphylococcus;    canine otitis treatment;    antimicrobial resistance;    multiresistant strains;    Fitoterapia;    oleorresina de copaíba;    Copaifera reticulata;    Staphylococcus;    tratamento da otite canina;    resistência antimicrobiana;    cepas multirresistentes;   

DOI  :  10.1590/S0100-736X2013000700011

来源: SciELO

【 摘 要 】

The aim of this study was to investigate the antimicrobial activity of the oleoresin Copaifera reticulata Ducke against Staphylococcus coagulase positive (SCP) isolated from otitis externa in dogs. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the oleoresin were determined by broth microdilution method. In addition, we verified the antimicrobial susceptibility profile of the isolates of SCP by agar diffusion method. Eight classes of antimicrobial were used to calculate the multidrug resistance. The chemical composition of the oleoresin was performed by gas chromatography coupled to the mass spectrometry (GC/MS), and β-caryophyllene, β-bisabolene, and (E)-α-bergamotene were the main compounds found. The copaiba oleoresin showed a MIC90 of 0.164mg/mL and a CBM90 of 1.3mg/mL. The multidrug resistance was found in 27% of the strains tested. The results suggest that copaiba oleoresin has bacteriostatic and bactericidal activity even in multidrug-resistant coagulase-positive strains.

【 授权许可】

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