Telomerase activity associated with progression of cervical lesions in a group of Colombian patients

Revista Brasileira de Ginecologia e Obstetrícia

Andrés Felipe Castro-duque¹  Nelsy Loango-chamorro¹  Bayron Manuel Ruiz-hoyos¹  Patricia Landázuri¹ 

关键词: Telomere;    Telomerase;    Cervix uteri;    Preneoplastic conditions;    Squamous intraepithelial lesions;    Telômeros;    Telomerase;    Colo do útero;    Condições pré-neoplásicas;    Lesões intraepiteliais escamosas;   

DOI  :  10.1590/SO100-720320150005462

来源: SciELO

【 摘 要 】

AbstractPURPOSE To analyze the relation between the cytological findings and telomerase activity (TA).METHODS Cervical samples were evaluated and classified according to the Bethesda System. Telomerase activity was measured total product generated values (TPG) using the TRAP assay (telomeric repeat amplification protocol); data were analyzed statistically using the χ2 test, with the level of significance set at p<0.05.RESULTS The study was conducted on 102 patients. Of these, 3.9% showed normal cytological findings, 8.8% showed cervicitis; 2% showed Atypical Squamous Cells of Undetermined Significance (ASCUS); 67.6% showed Low Grade Squamous Intraepithelial Lesion (LSIL); 11.8% showed High Grade Squamous Intraepithelial Lesion (H-SIL) and 5.9% showed Squamous Carcinoma. Among telomerase-positive samples, the TPG values were cervicitis

【 授权许可】

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