Comparative study of the different degrees of risk of gastrointestinal stromal tumor

Revista do Colégio Brasileiro de Cirurgiões

Rodrigo Panno Basilio De Oliveira¹  Pedro Eder Portari Filho¹  Antonio Carlos Iglesias¹  Carlos Alberto Basilio De Oliveira¹  Vera Lucia Nunes Pannain¹ 

关键词: Gastrointestinal Stromal Tumors;    Risk Factors;    Digestive System Neoplasms;    Prognosis;    Mitotic Index;    Tumores do Estroma Gastrointestinal;    Fatores de Risco;    Neoplasias do Sistema Digestório;    Prognóstico;    Índice Mitótico;   

DOI  :  10.1590/0100-69912015001007

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the applicability of the main categories of risk and morphological factors in the prognosis of gastrointestinal stromal tumors. METHODS: we retrospectively studied fifty-four cases of GIST, assessing the main prognostic factors of this neoplasis: risk levels, topography, size, mitotic index, necrosis, histological subtype and immunophenotype. We also verified their association and the reduction of overall survival. RESULTS: Univariate analysis showed that tumors with mitoses number greater than 5 per 50CGA (high-power fields), the presence of necrosis and a high risk for both the systems proposed by Fletcher and Miettinen had a significant association with reduced survival (p = 0.00001, 0.0056, 0.03 and 0.009, respectively). The remaining analyzed factors (size, histological subtype, topography and immunophenotype) had no such association. Multivariate analysis (Jacard index) showed that the Miettinen degree of risk was the one that best correlated with prognosis. CONCLUSION: the risk criteria of Fletcher and Miettinen are important in assessing the prognosis of patients with gastrointestinal stromal tumors, especially the latter, which adds to the mitotic index and the presence of tumor necrosis.

【 授权许可】

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