CFH Y402H polymorphism and response to intravitreal Ranibizumab in brazilian patients with neovascular age-related macular degeneration

Revista do Colégio Brasileiro de Cirurgiões

Carlos Eduardo Veloso¹  Luciana Negrão Frota De Almeida¹  Márcio Bittar Nehemy¹ 

关键词: Macular Degeneration;    Genetics;    Polymorphism;    Genetic;    Intravitreal Injections;    Retina;    Degeneração Macular;    Genética;    Polimorfismo Genético;    Injeções Intravítreas;    Retina;   

DOI  :  10.1590/0100-69912014006002

来源: SciELO

【 摘 要 】

Objective: To investigate the association between CFH gene polymorphism and response to ranibizumab in Brazilian patients with neovascular age-related macular degeneration (AMD).Methods: 95 patients were genotyped for the CFH rs1061170 (Y402H) single nucleotide polymorphism. Patients with neovascular AMD initially received intravitreal ranibizumab injections for three months and were retreated as needed. Visual acuity (VA) and central retinal thickness (CRT) were measured before treatment and at 1, 3, 6, and 12 months post-treatment.Results: For patients with the TT and TC genotypes, paired comparisons of VA showed a statistically significant improvement when the data obtained at all visits were compared with baseline. Patients homozygous for the risk genotype (CC) did not show a statistically significant improvement when VA obtained at visits 1, 3, 6 and 12 were compared with baseline. For all genotypes, paired comparisons of CRT showed a statistically significant improvement when the data obtained at visits 1, 3, 6 and 12 were compared with baseline.Conclusion: Patients with the CC genotype showed poorer long-term functional response to intravitreal ranibizumab.

【 授权许可】

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