Selective detection of fluoride based on a pyridinium n-phenolate-calix[4]pyrrole displacement assay: an undergraduate laboratory experiment

Química Nova

Karina Mannrich¹  Marcelo Silva¹  Leandro G. Nandi¹  Celso R. Nicoleti¹  Vanderlei G. Machado¹ 

[1] ,Universidade Federal de Santa Catarina Departamento de Química Florianópolis SC ,Brasil

关键词: calix[4];    pyrrole;    pyridinium N-phenolate betaine dyes;    displacement assay;    fluoride;    chromogenic chemosensors;   

DOI  :  10.5935/0100-4042.20140249

来源: SciELO

【 摘 要 】

A two-step experiment is proposed for a third year class in experimental organic chemistry. Over a period of five weeks, the students synthesized calix[4]pyrrole, a receptor that is highly selective for fluoride, and a pyridinium N-phenolate dye. Subsequently, the students used the synthesized compounds to investigate a displacement assay on the basis of the competition in acetonitrile between fluoride and the dye for calix[4]pyrrole. The experiment increased the students' skills in organic synthesis and in the characterization of organic compounds, provided a very attractive and accessible illustration of important supramolecular phenomena, and allowed the study of a chromogenic chemosensor.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License