Preparação de derivados do lapachol em meio ácido e em meio básico: uma proposta de experimentos para a disciplina de Química Orgânica Experimental

Química Nova

Ticiano Pereira Barbosa¹  Hermes Diniz Neto¹ 

[1] ,Faculdade de Ciências Médicas da ParaíbaJoão Pessoa PB ,Brasil

关键词: lapachol;    acid-base concepts;    chromatography;   

DOI  :  10.1590/S0100-40422013000200021

来源: SciELO

【 摘 要 】

In this educational paper we describe the extraction of lapachol from its natural source according to acid-base concepts in organic chemistry and the use of its derivatives β-lapachone and hydroxy-hydrolapachol to exemplify intramolecular cyclization, carbocation stability, Michael addition reaction and chromatography. The experiments were performed during three different undergraduate organic chemistry laboratory classes using low cost material, while avoiding color reagents for TLC visualization, as well as small-scale column chromatography to isolate the mixture of lapachol and β-lapachone.

【 授权许可】

CC BY-NC   
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