Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?

Química Nova

Marilia Valli¹  Marcos Pivatto¹  Amanda Danuello¹  Ian Castro-gamboa¹  Dulce Helena Siqueira Silva¹  Alberto José Cavalheiro¹  Ângela Regina Araújo¹  Maysa Furlan¹  Márcia Nasser Lopes¹  Vanderlan Da Silva Bolzani¹ 

[1] ,Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Química Departamento de Química OrgânicaAraraquara SP ,Brasil

关键词: natural products;    medicinal chemistry;    tropical biodiversity;   

DOI  :  10.1590/S0100-40422012001100036

来源: SciELO

【 摘 要 】

The use of natural products has definitely been the most successful strategy in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. This paper seeks to show the great value of secondary metabolites and emphasize the rich chemical diversity of Brazilian biodiversity. This natural chemical library remains understudied, but can be a useful source of new secondary metabolites with potential application as templates for drug discovery.

【 授权许可】

CC BY-NC   
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