Desenvolvimento, produção e caracterização de nanocristais de fármacos pouco solúveis

Química Nova

Joana F. Fangueiro²  Inês R. Marques²  Patrícia Severino¹  Maria Helena A. Santana¹  Eliana B. Souto¹ 

[1] ,Universidade Fernando Pessoa Faculdade de Ciências da Saúde Porto,Portugal

关键词: nancrystals;    microfluidization;    high pressure homogenization;   

DOI  :  10.1590/S0100-40422012000900025

来源: SciELO

【 摘 要 】

Poorly soluble drugs have low bioavailability, representing a major challenge for the pharmaceutical industry. Processing drugs into the nanosized range changes their physical properties, and these are being used in pharmaceutics to develop innovative formulations known as Nanocrystals. Use of nanocrystals to overcome the problem of low bioavailability, and their production using different techniques such as microfluidization or high pressure homogenization, was reviewed in this paper. Examples of drugs, cosmetics and nutraceutical ingredients were also discussed. These technologies are well established in the pharmaceutical industry and are approved by the Food and Drug Administration.

【 授权许可】

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