Determinação simultânea de ácido ascórbico e ácido acetilsalicílico usando análise por injeção em fluxo com detecção amperométrica pulsada

Química Nova

Joyce A. T. De Miranda¹  Rafael R. Cunha¹  Denise T. Gimenes¹  Rodrigo A. A. Munoz¹  Eduardo M. Richter¹ 

[1] ,Universidade Federal de Uberlândia Instituto de Química Uberlândia MG ,Brasil

关键词: simultaneous determination;    FIA;    multiple pulse amperometry;   

DOI  :  10.1590/S0100-40422012000700029

来源: SciELO

【 摘 要 】

A simple flow system with multiple pulse amperometric detection using a single working electrode is proposed for simultaneous determination of ascorbic (AA) and acetylsalicylic (AAS) acids in pharmaceutical formulations. The procedure is based on application of two potential pulses: 0.90 V/50 ms: oxidation and determination of AA without the interference of AAS; 1.35 V/50 ms: oxidation of both compounds and quantification of AAS by current subtraction using a correction factor. Sampling rate was estimated as 125 injections per hour and the limits of detection were 0.17 and 0.16 µmol L-1 for AA and AAS, respectively. Results for commercial samples agreed with those obtained using HPLC.

【 授权许可】

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