A reação "click" na síntese de 1,2,3-triazóis: aspectos químicos e aplicações

Química Nova

Luiza Baptista De Oliveira Freitas¹  Fernando Armini Ruela¹  Guilherme Rocha Pereira¹  Rosemeire Brondi Alves¹  Rossimiriam Pereira De Freitas¹  Leandro José Dos Santos² 

[1] ,Universidade Federal de Minas Gerais Instituto de Ciências Exatas Departamento de QuímicaBelo Horizonte MG ,Brasil

关键词: click;    reaction;    cycloaddition;    triazole;   

DOI  :  10.1590/S0100-40422011001000012

来源: SciELO

【 摘 要 】

The Copper-catalyzed azide-alkyne cycloaddition (CuAAC), often referred to as "click" reaction, has become a very popular reaction in the last years. It affords exclusively 1,4-disubstituted 1,2,3-triazoles and has been widely used to connect readily accessible building blocks containing various functional groups. The great success of this reaction is based on the fact that it is general, virtually quantitative and very robuste. The scope of this copper-catalyzed synthesis is extraordinary and the reaction has found numerous applications in many research fields, including biological chemistry and materials science. In this review, the main chemical aspects and applications of the "click" reaction in the synthesis of 1,2,3-triazoles are presented.

【 授权许可】

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