Simple and sensitive spectrophotometric methods for the analysis of mesalamine in bulk and tablet dosage forms

Química Nova

Bala Sekaran Chandra¹  Siva Santhosh Bhogela¹  Manjusha Shaik¹  Chaitanya Sravanthi Vadlamudi¹  Meghana Chappa¹  Naga Sirisha Maddirala¹ 

[1] ,J.K.C. College Department of Biotechnology Andhra Pradesh,India

关键词: mesalamine;    spectrophotometric analysis;    validation;   

DOI  :  10.1590/S0100-40422011000600026

来源: SciELO

【 摘 要 】

Three simple, sensitive, economical and reproducible spectrophotometric methods (A, B and C) are described for determination of mesalamine in pure drug as well as in tablet dosage forms. Method A is based on the reduction of tungstate and/or molybdate in Folin Ciocalteu's reagent; method B describes the reaction between the diazotized drug and α-naphthol and method C is based on the reaction of the drug with vanillin, in acidic medium. Under optimum conditions, mesalamine could be quantified in the concentration ranges, 1-30, 1-15 and 2-30 µg mL-1 by method A, B and C, respectively. All the methods have been applied to the determination of mesalamine in tablet dosage forms. Results of analysis are validated statistically.

【 授权许可】

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