Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads

Química Nova

Dalia Charles-navarro²  Virgilio Bocanegra-garcía²  Isidro Palos²  Gildardo Rivera²  Patricia Esquivel-ferriño¹  Sandra Gracia-vásquez¹  Rolffy Ortiz-andrade¹  Jesús Quiroz-velásquez¹  José Luis Hernández-mendoza¹ 

[1] ,Universidad Autónoma de Tamaulipas Departamento de Farmacia y Química Medicinal Reynosa,México

关键词: glibenclamide;    calcium-alginate beads;    dissolution;   

DOI  :  10.1590/S0100-40422010000700002

来源: SciELO

【 摘 要 】

The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 µm. For the in vitro dissolution test Daonil® at 45 min showed a Q > 70%, whereas Glibetab® and glibenclamide calcium-alginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties.

【 授权许可】

CC BY-NC   
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