Determination of 5-aminosalicylic acid in pharmaceutical formulations by square wave voltammetry at pencil graphite electrodes

Química Nova

Carolina V. Uliana²  Hideko Yamanaka²  Gustavo S. Garbellini¹  Giancarlo R. Salazar-banda¹ 

[1] ,Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Química Araraquara SP ,Brasil

关键词: 5-aminosalicylic acid;    pharmaceutical formulations;    pencil graphite electrode;   

DOI  :  10.1590/S0100-40422010000400036

来源: SciELO

【 摘 要 】

An analytical method for the determination of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA) in pharmaceutical formulations using square wave voltammetry at pencil graphite electrodes was developed. After the optimization of the experimental conditions, calibration curves were obtained in the linear concentration range from 9.78 × 10-7 to 7.25 × 10-5 mol L-1 resulting in a limit of detection of 2.12 ± 0.05 x 10-8 mol L-1. Statistical tests showed that the concentrations of 5-ASA in commercial tablets and enemas obtained with the proposed voltammetric method agreed with HPLC values at a 95% confidence level.

【 授权许可】

CC BY-NC   
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