Development of new dissolution test and HPLC-RP method for anti-parasitic ornidazole coated tablets

Química Nova

Mônica Felts De La Roca Soares²  José Lamartine Soares Sobrinho²  Severino Grangeiro Júnior¹  Keyla Emanuelle Ramos Da Silva¹  Lariza Darlene Santos Alves¹  Pedro José Rolim Neto¹ 

[1] ,Universidade Federal do Piauí Departamento de Bioquímica e Farmacologia Teresina PI ,Brasil

关键词: ornidazole;    quality control;    dissolution test;   

DOI  :  10.1590/S0100-40422010000200042

来源: SciELO

【 摘 要 】

This work aimed the development and validation of a new dissolution test for ornidazole coated tablets. The dissolution conditions were determined after testing Sink conditions, dissolution medium, apparatus, stirring speed, 24 h stability and medium filtration influence. The best conditions were paddle at a stirring speed of 75 rpm and 900 mL of 0.1 M HCl. A new HPLC quantification method was developed and validated. The dissolution test and quantification method showed to be adequate for their purposes and could be applied for quality control of ornidazole coated tablets, since there is no official monograph.

【 授权许可】

CC BY-NC   
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