Química Nova | |
Flow-injection spectrophotometric determination of tetracycline and doxycycline in pharmaceutical formulations using chloramine-T as oxidizing agent | |
José L. Rufino1  Patrícia L. Weinert1  Helena R. Pezza1  Leonardo Pezza1  | |
[1] ,Universidade Estadual Paulista Instituto de Química de Araraquara Araraquara SP ,Brasil | |
关键词: tetracyclines; flow-injection; spectrophotometry; | |
DOI : 10.1590/S0100-40422009000700016 | |
来源: SciELO | |
【 摘 要 】
A flow-injection (FI) spectrophotometric procedure is proposed for tetracycline (TC) and doxycycline (DXC) determination in pharmaceuticals. The method is based on the reaction of oxidation of these drugs by chloramine-T in alkaline medium producing red color products (λmax = 535 and 525 nm). Beer´s law is obeyed in the concentration range from 6.62 x 10-5 to 7.72 x 10-4 mol L-1 and 5.37 x 10-5 to 7.16 x 10-4 mol L-1 for TC and DXC, respectively. The analytical frequency was 50 h"1 and 45 h-1 for TC and DXC, respectively. The results obtained by the proposed method were in good agreement with those obtained by the official method at 95% confidence level.
【 授权许可】
CC BY-NC
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