Síntese e avaliação da atividade antimicrobiana de novas 4-tiazolidinonas obtidas a partir de formilpiridina tiossemicarbazonas

Química Nova

George Leonardo Verçoza²  Danniel Delmondes Feitoza²  Antônio José Alves²  Thiago Mendonça De Aquino²  José Gildo De Lima²  Janete Magali Araújo¹  Ivana Gláucia B. Cunha¹  Alexandre José Da Silva Góes¹ 

[1] ,Universidade Federal de Pernambuco Departamento de Ciências Farmacêuticas Recife PE ,Brasil

关键词: 4-thiazolidinones;    formilpyridine thiosemicarbazones;    antimicrobial activities;   

DOI  :  10.1590/S0100-40422009000600008

来源: SciELO

【 摘 要 】

Twelve novel 4-thiazolidinone derivatives (2a-l) have been synthesized by reacting formilpyridine thiosemicarbazones (1a-l) and anhydride maleic in toluene. Their chemical structures were confirmed by IR, ¹H and 13C NMR. The new compounds were submitted to in vitro evaluation against pathogenic Gram-positive, Gram-negative bacteria and yeasts. The findings obtained showed that the compounds 2a, 2d, 2e and 2g were effective against some of the bacterial strains used, whereas the compounds 2d, 2e and 2i exhibited a moderate antifungal activity against the yeast strains evaluated. An initial structure activity relationship (SAR) was established.

【 授权许可】

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