Avaliação da biodegradação de matrizes porosas à base de hidroxiapatita para aplicação como fontes radioativas em braquiterapia

Química Nova

Kássio André Lacerda²  Fernando Soares Lameiras²  Viviane Viana Silva¹ 

[1] ,Comissão Nacional de Energia Nuclear Centro de Desenvolvimento da Tecnologia Nuclear Belo Horizonte MG ,Brasil

关键词: hydroxyapatite;    biodegradation;    brachytherapy;   

DOI  :  10.1590/S0100-40422009000500025

来源: SciELO

【 摘 要 】

Porous ceramic materials based on calcium phosphate compounds (CPC) have been studied aiming at different biomedical applications such as implants, drug delivery systems and radioactive sources for brachytherapy. Two kinds of hydroxyapatite (HAp) powders and their ceramic bodies were characterized by a combination of different techniques (XRF, BET method, SEM, ICP/AES and neutron activation analysis - NAA) to evaluate their physico-chemical and microstructural characteristics in terms of chemical composition, segregated phases, microstructure, porosity, chemical and thermal stability, biodegradation and incorporation of substances in their structures. The results revealed that these systems presented potential for use as porous biodegradable radioactive sources able to be loaded with a wide range of radionuclides for cancer treatment by the brachytherapy technique.

【 授权许可】

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