Princípios básicos e aplicação da iontoforese na penetração cutânea de fármacos

Química Nova

Taís Gratieri¹  Guilherme Martins Gelfuso¹  Renata Fonseca Vianna Lopez¹ 

[1] ,Universidade de São Paulo Faculdade de Ciências Farmacêuticas de Ribeirão Preto Ribeirão Preto SP ,Brasil

关键词: iontophoresis;    topic and transdermal delivery;    electrorepulsion;   

DOI  :  10.1590/S0100-40422008000600040

来源: SciELO

【 摘 要 】

Physicochemical constraints severely limit the number of molecules that can be considered as candidates for transdermal delivery. Iontophoresis is a non-invasive technique in which a weak electric current is used to enhance the penetration of molecules into or through the skin. In this review the underlying mechanisms that drive iontophoresis and the impact of key experimental parameters - namely, formulation, drug concentration and pH - on iontophoretic delivery efficiency are discussed. In the final section some devices that are currently commercialized are also described.

【 授权许可】

CC BY-NC   
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