A multi-screening approach for marine-derived fungal metabolites and the isolation of cyclodepsipeptides from Beauveria felina

Química Nova

Aline Maria De Vita-marques²  Simone P. Lira²  Roberto G. S. Berlinck²  Mirna H. R. Seleghim¹  Sandra R. P. Sponchiado¹  Sâmia M. Tauk-tornisielo¹  Margarida Barata¹  Claudia Pessoa¹  Manoel O. De Moraes¹  Bruno Coêlho Cavalcanti¹  Gislene G. F. Nascimento¹  Ana O. De Souza¹  Fabio C. S. Galetti¹  Célio L. Silva¹  Marcio Silva¹  Eli F. Pimenta¹  Otavio Thiemann¹  Michel R. Z. Passarini¹  Lara D. Sette¹ 

[1] ,Universidade de São Paulo Instituto de Química de São Carlos São Carlos SP ,Brazil

关键词: marine-derived fungi;    screening;    Beauveria felina;   

DOI  :  10.1590/S0100-40422008000500030

来源: SciELO

【 摘 要 】

Extracts obtained from 57 marine-derived fungal strains were analyzed by HPLC-PDA, TLC and ¹H NMR. The analyses showed that the growth conditions affected the chemical profile of crude extracts. Furthermore, the majority of fungal strains which produced either bioactive of chemically distinctive crude extracts have been isolated from sediments or marine algae. The chemical investigation of the antimycobacterial and cytotoxic crude extract obtained from two strains of the fungus Beauveria felina have yielded cyclodepsipeptides related to destruxins. The present approach constitutes a valuable tool for the selection of fungal strains that produce chemically interesting or biologically active secondary metabolites.

【 授权许可】

CC BY-NC   
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