Estrutura, reatividade e propriedades biológicas de hidantoínas

Química Nova

Silvânia Maria De Oliveira²  João Bosco Paraíso Da Silva²  Marcelo Zaldini Hernandes¹  Maria Do Carmo Alves De Lima¹  Suely Lins Galdino¹  Ivan Da Rocha Pitta¹ 

[1] ,Universidade Federal de Pernambuco Departamento de Química Fundamental Recife PE ,Brasil

关键词: hydantoin;    reactivity;    biological properties;   

DOI  :  10.1590/S0100-40422008000300029

来源: SciELO

【 摘 要 】

Hydantoin (imidazolidine-2,4-dione) is a 2,4-diketotetrahydroimidazole discovered by Baeyer in 1861. Thiohydantoins and derivatives were prepared, having chemical properties similar to the corresponding carbonyl compounds. Some biological activities (antimicrobial, anticonvulsant, schistosomicidal) are attributed to the chemical reactivity and consequent affinity of hydantoinic rings towards biomacromolecules. Therefore, knowledge about the chemistry of hydantoins has increased enormously. In this review, we present important aspects such as reactivity of hydantoins, acidity of hydantoins, spectroscopy and cristallographic properties, and biological activities of hydantoin and its derivatives.

【 授权许可】

CC BY-NC   
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