Síntese, avaliação biológica e modelagem molecular de arilfuranos como inibidores da enzima tripanotiona redutase

Química Nova

Renata B. De Oliveira²  Carlos L. Zani²  Rafaela S. Ferreira²  Rodrigo S. Leite²  Tânia M. A. Alves²  Thaís H. A. Da Silva¹  Alvaro J. Romanha¹ 

[1] ,Fiocruz Centro de Pesquisas René Rachou Laboratório de Química de Produtos NaturaisBelo Horizonte MG ,Brasil

关键词: trypanothione reductase;    molecular modeling;    arylfurans;   

DOI  :  10.1590/S0100-40422008000200013

来源: SciELO

【 摘 要 】

Trypanosoma cruzi is a protozoan parasite that causes a severe disease (Chagas'disease) in Central and South America. The currently available chemotherapeutic agents against this disease are still inadequate. The enzyme trypanothione reductase (TR) is considered a validated molecular target for the development of new drugs against this parasite. In this regard, a series of arylfurans based on 2,5-bis-(4-acetamidophenyl)furan was synthesized and tested for their in vitro inhibitory activity against TR. Molecular modeling studies of putative enzyme-inhibitor complexes revealed a possible mechanism of interaction. From synthesized compounds, a benzylaminofuran derivative was found to be more active than the lead compound.

【 授权许可】

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