Chemical constituents from Bakeridesia pickelii Monteiro (Malvaceae) and the relaxant activity of kaempferol-3-O-beta-D-(6"-E-p -coumaroyl) glucopyranoside on guinea-pig ileum

Química Nova

Danielly Albuquerque Da Costa¹  Davi Antas E Silva¹  Aline Coutinho Cavalcanti¹  Marcos Antônio Alves De Medeiros¹  Julianeli Tolentino De Lima¹  José Marcílio Sobral Cavalcante¹  Bagnólia Araújo Da Silva¹  Maria De Fátima Agra¹  Maria De Fátima Vanderlei De Souza¹ 

关键词: malvaceae;    Bakeridesia pickelii;    relaxant activity;   

DOI  :  10.1590/S0100-40422007000400026

来源: SciELO

【 摘 要 】

The phytochemical investigation of Bakeridesia pickelii Monteiro led to the isolation of seven compounds: beta-sitosterol, a mixture of sitosteryl-3-O-beta-D-glucopyranoside and stigmasteryl-3-O-beta-D-glucopyranoside, vanillic acid, p-coumaric acid, quercetin 3-O-beta-D-glucopyranoside (isoquercitrin) and kaempferol-3-O-beta-D-(6"-E-p -coumaroyl) glucopyranoside (tiliroside), which was isolated as the major component. Their structures were elucidated on the basis of spectroscopic data such as IR, ¹H and 13C NMR, including two-dimensional techniques. Tiliroside relaxed the guinea-pig ileum pre-contracted with KCl 40 mM (EC50 = 9.5 ± 1.0 x 10-5 M), acetylcholine 10-6 M (EC50 = 2.3 ± 0.9 x 10-5 M) or histamine 10-6 M (EC50 = 4.1 ± 1.0 x 10-5 M) in a concentration-dependent manner.

【 授权许可】

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