Metil coenzima M redutase (MCR) e o fator 430 (F430)

Química Nova

Shirley Nakagaki¹  Geraldo Roberto Friedermann¹  José Maurício Almeida Caiut¹ 

[1] ,Universidade Federal do Paraná Departamento de Química Curitiba PR ,Brasil

关键词: nickel complexes;    coenzyme M reductase;    F430;   

DOI  :  10.1590/S0100-40422006000500022

来源: SciELO

【 摘 要 】

This review presents studies on methyl coenzyme M reductase, the biological system Factor 430 (F430) and the use of nickel(II) complexes as structural and functional models. The ability of F430 and nickel(II) macrocycle complexes to mediate the reductive dehalogenation of cyclohexyl halogens and the CH3-S bond cleavage of methyl CoM (by sodium borohydride and some intermediate species) proposed for the catalytic cycle of the biological system F430 was reviewed. The importance of the structure of the nickel complexes and the condition of the catalytic reduction reaction are also discussed.

【 授权许可】

CC BY-NC   
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