Determinação turbidimétrica de dipirona em fluxo utilizando um reator contendo cloreto de prata imobilizado em resina poliéster

Química Nova

Luiz H. Marcolino-jr.¹  Viviane Gomes Bonifácio¹  Orlando Fatibello-filho¹  Marcos F. S. Teixeira² 

[1] ,Universidade Federal de São Carlos Centro de Ciências Exatas e de Tecnologia Departamento de QuímicaSão Carlos SP

关键词: dipyrone;    flow injection turbidimetry;    solid-phase reactor;   

DOI  :  10.1590/S0100-40422005000500009

来源: SciELO

【 摘 要 】

A simple flow injection procedure was developed for determining dipyrone (1-phenyl-2,3-dimethyl-4-methylaminomethano-5-pyrazolone sodium, metamizol, analgin) in pharmaceutical formulations. The determination is based on the reduction of Ag+ ions to Ag0 by dipyrone. A colloidal suspension of Ag0 produced was transported by carrier solution (0.01 mol L-1 NaOH) and turbidimetrically detected at 425 nm. The analytical curve for dipyrone was linear in the range from 5.0 x 10-4 to 2.5 x 10-3 mol L-1 with a correlation coefficient of 0.9990. The detection limit was 1.3 x 10-4 mol L-1 (3sigmaB/slope). The relative standard deviation for ten successive measurements was 1.8% and an analytical frequency of 45 h-1 was obtained. The recovery values from three samples ranged from 96.0 to 102%.

【 授权许可】

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