Aspectos regio- e estereoquímicos da adição de Michael assimétrica via iminas quirais com centros estereogênicos pré-existentes

Química Nova

Rossana A. Schenato²  Éverton M. Dos Santos¹  Beatriz S. M. Tenius¹  Eduardo R. De Oliveira¹ 

[1] ,Universidade Católica do Rio Grande do Sul Faculdade de Química Porto Alegre RS

关键词: deracemizing alkylation process;    chiral imines;    transmission of chirality;   

DOI  :  10.1590/S0100-40422003000500016

来源: SciELO

【 摘 要 】

The asymmetric Michael addition reactions using chiral imines, under neutral conditions (deracemizing alkylation process), constitute one of the main methods for the stereocontrolled elaboration of quaternary carbon centers. This protocol is based on the conjugate addition of secondary chiral enamines to electron-deficient alkenes. The focus of this report deals with the discussion of regio- and stereochemical aspects of the deracemizing alkylation process concerning enamines bearing a resident chiral center.

【 授权许可】

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