Análise de glicocorticosteróides por CG-EM: uma nova abordagem de derivatização para o controle de dopagem no esporte

Química Nova

Henrique M. G. Pereira¹  Marlice A. S. Marques¹  Jarí N. Cardoso¹  Francisco R. Aquino Neto¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Química Rio de Janeiro RJ

关键词: glucocorticosteroids;    GC-MS;    doping control;   

DOI  :  10.1590/S0100-40422002000700010

来源: SciELO

【 摘 要 】

Glucocorticosteroids (CT) show a powerful anti-inflammatory effect. In view of this, they are extensively used in sports medicine, but their misuse (systemic administration) can lead to severe injuries on athletes and has been restricted by the IOC in recent years. For GC-MS analysis, a derivatization step is necessary in order to convert them to a stable form, thus preventing thermal breakdown with the loss of the ketone side chain. Derivatization of CT is reviewed and a new approach of silylation is presented for screening of CT in urine.

【 授权许可】

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