O impacto do crômio nos sistemas biológicos

Química Nova

Alba Denise De Queiroz Ferreira¹ 

[1] ,Universidade Federal de São Carlos Departamento de Química São Carlos SP

关键词: chromium;    model compounds;    DNA;    insulin;   

DOI  :  10.1590/S0100-40422002000400012

来源: SciELO

【 摘 要 】

The impact of biological chromium's activity may be beneficial or not. This review presents the most relevant chemical aspects of these "two faces" of chromium by covering first, the efforts toward a clearer understanding of the carcinogenic properties of chromium compounds. The biomimetic chemistry of Cr(V) complexes illustrates the interactions of the intermediates formed by Cr(VI) reduction with DNA or oligonucleotides. The importance of trivalent chromium as an essential element is also emphasized by summarizing the recent results of the investigations on trinuclear chromium complexes as models of the cofactor responsible for the insulin activity, as well as good candidates for new nutritional supplements.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License