Complexação da tetraciclina, da oxitetraciclina e da clortetraciclina com o catião cobre (II). Estudo potenciométrico

Química Nova

Cristina M. C. M. Couto¹  M. Conceição B. S. M. Montenegro¹  Salette Reis¹ 

[1] ,Faculdade de Farmácia do Porto CEQUP - Departamento de Química Física Porto,Portugal

关键词: tetracycline;    copper (II);    complex formation;   

DOI  :  10.1590/S0100-40422000000400005

来源: SciELO

【 摘 要 】

Stability constants of complexes formed by copper (II) with three different tetracyclines (tetracycline, oxytetracycline and chlortetracycline) have been determined potentiometrically with an automatic system in aqueous medium at 25,0 ± 0,2 ºC and I = 0,1 mol L-1 NaNO3. The protonation constants of the three tetracyclines were also determined under the same conditions. The distribution of the complexes was then simulated at therapeutic levels of the drugs.

【 授权许可】

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