Prediction of preeclampsia by means of Doppler flowmetry of uterine artery and flow-mediated dilation of brachial artery

Radiologia Brasileira

Aline Costa Calixto¹  Augusto Henriques Fulgêncio Brandão¹  Luana Lopes Toledo¹  Henrique Vítor Leite¹  Antônio Carlos Vieira Cabral¹ 

关键词: Preeclampsia;    Doppler flowmetry;    Vascular endothelium;    Prediction;    Pré-eclâmpsia;    Dopplerfluxometria;    Endotélio vascular;    Predição;   

DOI  :  10.1590/S0100-39842014000100008

来源: SciELO

【 摘 要 】

ObjectiveTo evaluate the association of Doppler of uterine artery and flow-mediated dilation of brachial artery (FMD) in the assessment of placental perfusion and endothelial function to predict preeclampsia.Materials and MethodsA total of 91 patients considered as at risk for developing preeclampsia were recruited at the prenatal unit of the authors' institution. All the patients underwent FMD and Doppler of uterine arteries between their 24th and 28th gestational weeks. Calculations of sensitivity and specificity for both isolated and associated methods were performed.ResultsNineteen out of the 91 patients developed preeclampsia, while the rest remained normotensive. Doppler flowmetry of uterine arteries with presence of bilateral protodiastolic notch had sensitivity of 63.1% and specificity of 87.5% for the prediction of preeclampsia. Considering a cutoff value of 6.5%, FMD showed sensitivity of 84.2% and specificity of 73.6%. In a parallel analysis, as the two methods were associated, sensitivity was 94.2% and specificity, 64.4%.ConclusionThe association of Doppler study of uterine arteries and FMD has proved to be an interesting clinical strategy for the prediction of preeclampsia, which may represent a positive impact on prenatal care of patients considered as at high-risk for developing such a condition.

【 授权许可】

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