Effects of penicillin and erythromycin on adherence of invasive and noninvasive isolates of Streptococcus pyogenes to laminin

Memórias do Instituto Oswaldo Cruz

Aleksandra Šmitran¹  Dragana Vuković¹  Ina Gajić¹  Jelena Marinković¹  Lazar Ranin¹ 

关键词: Streptococcus pyogenes;    adherence;    laminin;    penicillin;    erythromycin;   

DOI  :  10.1590/0074-02760150092

来源: SciELO

【 摘 要 】

This study investigated the possible relationship between the invasiveness of group A Streptococcus (GAS) strains and their abilities to adhere to laminin and assessed the effects of subinhibitory concentrations of penicillin and erythromycin on the ability of GAS to adhere to laminin. The adherence of noninvasive and highly invasive isolates of GAS to laminin was significantly higher than the adherence displayed by isolates of low invasiveness. Antibiotic treatment caused significant reductions in adherence to laminin in all three groups of strains. Penicillin was more successful in reducing the adherence abilities of the tested GAS strains than erythromycin.

【 授权许可】

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