Infection with Trypanosoma cruzi TcII and TcI in free-ranging population of lion tamarins (Leontopithecus spp): an 11-year follow-up

Memórias do Instituto Oswaldo Cruz

Cristiane Varella Lisboa¹  Rafael Veríssimo Monteiro¹  Andreia Fonseca Martins¹  Samantha Cristina Das Chagas Xavier¹  Valdirene Dos Santos Lima¹  Ana Maria Jansen¹ 

关键词: Trypanosoma cruzi;    wild free-ranging mammals;    Atlantic Rainforest;    reservoir host;    sylvatic transmission cycle;    discrete typing unit;    DTU;   

DOI  :  10.1590/0074-02760140400

来源: SciELO

【 摘 要 】

Here, we present a review of the dataset resulting from the 11-years follow-up of Trypanosoma cruziinfection in free-ranging populations of Leontopithecus rosalia(golden lion tamarin) andLeontopithecus chrysomelas(golden-headed lion tamarin) from distinct forest fragments in Atlantic Coastal Rainforest. Additionally, we present new data regarding T. cruziinfection of small mammals (rodents and marsupials) that live in the same areas as golden lion tamarins and characterisation at discrete typing unit (DTU) level of 77 of these isolates. DTU TcII was found to exclusively infect primates, while TcI infectedDidelphis aurita and lion tamarins. The majority ofT. cruziisolates derived from L. rosaliawere shown to be TcII (33 out 42) Nine T. cruziisolates displayed a TcI profile. Golden-headed lion tamarins demonstrated to be excellent reservoirs of TcII, as 24 of 26 T. cruziisolates exhibited the TcII profile. We concluded the following: (i) the transmission cycle of T. cruziin a same host species and forest fragment is modified over time, (ii) the infectivity competence of the golden lion tamarin population fluctuates in waves that peak every other year and (iii) both golden and golden-headed lion tamarins are able to maintain long-lasting infections by TcII and TcI.

【 授权许可】

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