Interferon-γ inhibits group B Streptococcus survival within human endothelial cells

Memórias do Instituto Oswaldo Cruz

Viviane De Oliveira Freitas Lione¹  Michelle Hanthequeste Bittencourt Dos Santos¹  Jessica Silva Santos De Oliveira¹  Ana Luiza Mattos-guaraldi¹  Prescilla Emy Nagao¹ 

关键词: group B Streptococcus;    IFN-γ;    survival;   

DOI  :  10.1590/0074-0276140201

来源: SciELO

【 摘 要 】

Endothelial dysfunction is a major component of the pathophysiology of septicaemic group B Streptococcus (GBS) infections. Although cytokines have been shown to activate human umbilical vein endothelial cells (HUVECs), the capacity of interferon (IFN)-γ to enhance the microbicidal activity of HUVECs against GBS has not been studied. We report that the viability of intracellular bacteria was reduced in HUVECs activated by IFN-γ. Enhanced fusion of lysosomes with bacteria-containing vacuoles was observed by acid phosphatase and the colocalisation of Rab-5, Rab-7 and lysosomal-associated membrane protein-1 with GBS in IFN-γ-activated HUVECs. IFN-γ resulted in an enhancement of the phagosome maturation process in HUVECs, improving the capacity to control the intracellular survival of GBS.

【 授权许可】

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