DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients

Memórias do Instituto Oswaldo Cruz

Ludovica Segat¹  Luisa Zupin¹  Ronald Rodrigues Moura¹  Antonio Victor Campos Coelho¹  Bárbara Simas Chagas¹  Antonio Carlos De Freitas¹  Sergio Crovella¹ 

关键词: antimicrobial peptides;    human papillomavirus;    genetic polymorphisms;    cervical lesion;   

DOI  :  10.1590/0074-0276140220

来源: SciELO

【 摘 要 】

The human beta defensin 1 (hBD-1) antimicrobial peptide is a member of the innate immune system known to act in the first line of defence against microorganisms, including viruses such as human papillomavirus (HPV). In this study, five functional polymorphisms (namely g-52G>A, g-44C>G and g-20G>A in the 5’UTR and c.*5G>A and c.*87A>G in the 3’UTR) in the DEFB1 gene encoding for hBD-1 were analysed to investigate the possible involvement of these genetic variants in susceptibility to HPV infection and in the development of HPV-associated lesions in a population of Brazilian women. The DEFB1 g-52G>A and c.*5G>A single-nucleotide polymorphisms (SNPs) and the GCAAA haplotype showed associations with HPV-negative status; in particular, the c.*5G>A SNP was significantly associated after multiple test corrections. These findings suggest a possible role for the constitutively expressed beta defensin-1 peptide as a natural defence against HPV in the genital tract mucosa.

【 授权许可】

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