A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the Mexico/United States border

Memórias do Instituto Oswaldo Cruz

Pola Becerril-montes¹  Salvador Said-fernández¹  Julieta Luna-herrera¹  Guillermo Caballero-olín¹  José Antonio Enciso-moreno¹  Herminia Guadalupe Martínez-rodríguez¹  Gerardo Padilla-rivas¹  Elsa Nancy-garza-treviño¹  Gloria María Molina-salinas¹ 

关键词: tuberculosis;    Mycobacterium tuberculosis;    first and second-line drug resistance;   

DOI  :  10.1590/0074-0276108022013006

来源: SciELO

【 摘 要 】

The resistance of 139 Mycobacterium tuberculosis (MTB) isolates from the city of Monterrey, Northeast Mexico, to first and second-line anti-TB drugs was analysed. A total of 73 isolates were susceptible and 66 were resistant to anti-TB drugs. Monoresistance to streptomycin, isoniazid (INH) and ethambutol was observed in 29 cases. Resistance to INH was found in 52 cases and in 29 cases INH resistance was combined with resistance to two or three drugs. A total of 24 isolates were multidrug-resistant (MDR) resistant to at least INH and rifampicin and 11 MDR cases were resistant to five drugs. The proportion of MDR-TB among new TB cases in our target population was 0.72% (1/139 cases). The proportion of MDR-TB among previously treated cases was 25.18% (35/139 cases). The 13 polyresistant and 24 MDR isolates were assayed against the following seven second-line drugs: amikacin (AMK), kanamycin (KAN), capreomycin (CAP), clofazimine (CLF), ethionamide (ETH), ofloxacin (OFL) and cycloserine (CLS). Resistance to CLF, OFL or CLS was not observed. Resistance was detected to ETH (10.80%) and to AMK (2.70%), KAN (2.70%) and CAP (2.70%). One isolate of MDR with primary resistance was also resistant to three second-line drugs. Monterrey has a high prevalence of MDR-TB among previously treated cases and extensively drug-resistant-MTB strains may soon appear.

【 授权许可】

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