Brazilian clinical trial of uniform multidrug therapy for leprosy patients: the correlation between clinical disease types and adverse effects

Memórias do Instituto Oswaldo Cruz

Heitor De Sá Gonçalves²  Maria Araci De Andrade Pontes²  Samira Bührer-sékula¹  Rossilene Cruz¹  Paulo Cesar Almeida¹  Maria Elisabete Amaral De Moraes¹  Gerson Oliveira Penna¹ 

[1] ,Centro de Referência Dona LibaniaFortaleza CE ,Brasil

关键词: leprosy;    multibacillary leprosy;    paucibacillary leprosy;    adverse effects;    therapeutics;    leprostatic agents;   

DOI  :  10.1590/S0074-02762012000900013

来源: SciELO

【 摘 要 】

This study sought to verify the correlation between leprosy types and the adverse effects of treatment drugs. This quantitative, prospective, nested study was developed at the Dona Libânia Dermatology Centre in Fortaleza, Brazil. Data were collected from November 2007-November 2008. During this period, 818 leprosy patients were diagnosed and began treatment. Forty patients with tuberculoid leprosy (TT) were selected. Twenty patients followed a standard therapy of dapsone and rifampicin and 20 were administered dapsone, rifampicin and clofazimine (U-MDT). Twenty patients with borderline lepromatous (BL) and lepromatous leprosy (LL) were also selected and treated with U-MDT. All of the subjects received six doses. With the exception of haemolytic anaemia, there was a low incidence of adverse effects in all the groups. We did not observe any differences in the incidence of haemolytic anaemia or other side effects across groups of patients with TT, BL or LL treated with U-MDT.

【 授权许可】

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