Use of the Kala-Azar Detect® and IT-LEISH® rapid tests for the diagnosis of visceral leishmaniasis in Brazil

Memórias do Instituto Oswaldo Cruz

Vanessa Peruhype-magalhães¹  Tália Santana Machado-de-assis¹  Ana Rabello¹ 

[1] ,Fiocruz Centro de Pesquisas René Rachou Laboratório de Pesquisas ClínicasBelo Horizonte MG ,Brazil

关键词: visceral leishmaniasis;    diagnosis;    rapid test;   

DOI  :  10.1590/S0074-02762012000700019

来源: SciELO

【 摘 要 】

The performances of two rapid tests and a standard serological test for the diagnosis of visceral leishmaniasis (VL) were compared using sera from 193 patients with VL and 85 controls. The Kala-Azar Detect®, IT-LEISH® and IFI-LH® assays showed sensitivities of 88.1%, 93.3% and 88.6%, respectively, and specificities of 90.6%, 96.5% and 80%, respectively. The sensitivity values were similar for both rapid tests, but the specificity and positive predictive values of IT-LEISH® were higher than the corresponding values for IFI-LH®. Both rapid tests showed satisfactory performances and can be used in primary health care settings; however, IT-LEISH® permits the use of whole blood, making this assay more suitable for bedside diagnosis.

【 授权许可】

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