Changing the epidemiology of carbapenem-resistant Pseudomonas aeruginosa in a Brazilian teaching hospital: the replacement of São Paulo metallo-β-lactamase-producing isolates

Memórias do Instituto Oswaldo Cruz

Felipe Lira De Sá Cavalcanti²  Anna Carolina Soares Almeida²  Marinalda Anselmo Vilela²  Marcia Maria Camargo De Morais²  Marcos Antonio De Morais Junior¹ 

[1] ,Universidade de Pernambuco Instituto de Ciências Biológicas Laboratório de Resistência MicrobianaRecife PE ,Brasil

关键词: carbapenemases;    metallo-β-lactamase;    Pseudomonas aeruginosa;   

DOI  :  10.1590/S0074-02762012000300019

来源: SciELO

【 摘 要 】

In Brazil, carbapenem-resistant Pseudomonas aeruginosa isolates are closely related to the São Paulo metallo-β-lactamase (SPM) Brazilian clone. In this study, imipenem-resistant isolates were divided in two sets, 2002/2003 and 2008/2009, analysed by pulsed field gel electrophoresis and tested for the Ambler class B metallo-β-lactamase (MBL) genes blaSPM-1, blaIMP and blaVIM. The results show a prevalence of one clone related to the SPM Brazilian clone in 2002/2003. In 2008/2009, P. aeruginosa isolates were mostly MBL negative, genetically diverse and unrelated to those that had been detected earlier. These findings suggest that the resistance to carbapenems by these recent P. aeruginosa isolates was not due to the spread of MBL-positive SPM-related clones, as often observed in Brazilian hospitals.

【 授权许可】

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