Co-infections associated with human immunodeficiency virus type 1 in pregnant women from southern Brazil: high rate of intraepithelial cervical lesions

Memórias do Instituto Oswaldo Cruz

Michele Tornatore²  Carla Vitola Gonçalves²  Mônica Steigleder Bianchi²  Fabiana Nunes Germano¹  Alzira Xavier Garcés²  Marcelo Alves Soares¹  Elizabeth Stankiewicz Machado¹  Ana Maria Barral De Martinez² 

[1] ,Universidade Federal do Rio Grande Faculdade de Medicina Rio Grande RS ,Brazil

关键词: pregnancy;    HIV-1;    co-infections;    STDs;    cervical carcinoma;   

DOI  :  10.1590/S0074-02762012000200009

来源: SciELO

【 摘 要 】

Human immunodeficiency virus type 1 (HIV-positive) pregnant women require specific prophylactic and therapeutic approaches. The efficacy of established approaches is further challenged by co-infection with other sexually transmitted diseases (STDs). The objective of this study was to determine the prevalence of co-infections in pregnant women infected with different HIV-1 subtypes and to relate these findings, together with additional demographic and clinical parameters, to maternal and infant outcomes. Blood samples from pregnant women were collected and tested for syphilis, hepatitis B virus (HBV) and hepatitis C virus (HCV). Human papillomavirus (HPV) diagnosis was evaluated by the presence of alterations in the cervical epithelium detected through a cytopathological exam. Medical charts provided patient data for the mothers and children. Statistical analyses were conducted with STATA 9.0. We found a prevalence of 10.8% for HCV, 2.3% for chronic HBV, 3.1% for syphilis and 40.8% for HPV. Of those co-infected with HPV, 52.9% presented high-grade intraepithelial lesions or in situ carcinoma. Prematurity, birth weight, Apgar 1' and 5' and Capurro scores were similar between co-infected and non-co-infected women. The presence of other STDs did not impact maternal and concept outcomes. More than half of the patients presenting cervical cytology abnormalities suggestive of HPV had high-grade squamous intraepithelial lesions or cervical cancer, evidencing an alarming rate of these lesions.

【 授权许可】

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