The in vitro leishmanicidal activity of hexadecylphosphocholine (miltefosine) against four medically relevant Leishmania species of Brazil

Memórias do Instituto Oswaldo Cruz

Eliane De Morais-teixeira¹  Quesia Souza Damasceno¹  Mariana Kolos Galuppo¹  Alvaro José Romanha²  Ana Rabello¹ 

[1] ,Centro de Pesquisas René Rachou-Fiocruz Laboratório de Pesquisas Clínicas Belo Horizonte MG ,Brasil

关键词: Leishmania;    miltefosine;    in vitro drug evaluation;   

DOI  :  10.1590/S0074-02762011000400015

来源: SciELO

【 摘 要 】

The in vitro leishmanicidal activity of miltefosine® (Zentaris GmbH) was assessed against four medically relevant Leishmania species of Brazil: Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, Leishmania (Viannia) guyanensis and Leishmania (Leishmania) chagasi. The activity of miltefosine against these New World species was compared to its activity against the Old World strain, Leishmania (Leishmania) donovani, which is known to be sensitive to the effects of miltefosine. The IC50 and IC90 results suggested the New World species harboured similar in vitro susceptibilities to miltefosine; however, miltefosine was approximately 20 times more active against the Old World L. (L.) donovani than against the New World L. (L.) chagasi species. The selectivity index varied from 17.2-28.9 for the New World Leishmania species and up to 420.0 for L. (L.) donovani. The differences in susceptibility to miltefosine suggest that future clinical trials with this drug should include a laboratory pre-evaluation and a dose-defining step.

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