Memórias do Instituto Oswaldo Cruz | |
Green propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines | |
Geferson Fischer2  Niraldo Paulino1  Maria C Marcucci1  Bianca S Siedler1  Lívia S Munhoz1  Paula F Finger1  Gilberto D Vargas1  Sílvia O Hübner1  Telmo Vidor1  Paulo M Roehe2  | |
[1] ,Universidade Federal do Rio Grande do Sul Centro de Ciências Básicas da Saúde | |
关键词: propolis; phenolic compounds; vaccines; humoral immunity; cellular immunity; | |
DOI : 10.1590/S0074-02762010000700012 | |
来源: SciELO | |
【 摘 要 】
Adjuvants play an important role in vaccine formulations by increasing their immunogenicity. In this study, the phenolic compound-rich J fraction (JFR) of a Brazilian green propolis methanolic extract stimulated cellular and humoral immune responses when co-administered with an inactivated vaccine against swine herpesvirus type 1 (SuHV-1). When compared to control vaccines that used aluminium hydroxide as an adjuvant, the use of 10 mg/dose of JFR significantly increased (p < 0.05) neutralizing antibody titres against SuHV-1, as well as the percentage of protected animals following SuHV-1 challenge (p < 0.01). Furthermore, addition of phenolic compounds potentiated the performance of the control vaccine, leading to increased cellular and humoral immune responses and enhanced protection of animals after SuHV-1 challenge (p < 0.05). Prenylated compounds such as Artepillin C that are found in large quantities in JFR are likely to be the substances that are responsible for the adjuvant activity.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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