Protective immunity against Trypanosoma cruzi

Memórias do Instituto Oswaldo Cruz

Cecilia Parodi¹  Angel Marcelo Padilla¹  Miguel Angel Basombrío¹ 

[1] ,Universidad Nacional de Salta Consejo Nacional de Investigaciones Científicas y Técnicas Instituto de Patología Experimental,Argentina

关键词: Trypanosoma cruzi;    immunity;    CD8+ T cells;   

DOI  :  10.1590/S0074-02762009000900038

来源: SciELO

【 摘 要 】

Upon infection, Trypanosoma cruzi triggers a strong immune response that has both protective and pathological consequences. In this work, several important questions regarding protective immunity are reviewed. Emphasis is placed on recent studies of the important protective role of CD8+ T cells and on previous studies of immunisation of domestic T. cruzi reservoirs that sought to address practical vaccination problems. Research on the maturation of memory cells and studies indicating that the prevalence of T. cruzi-specific T-cell responses and a high frequency of committed CD8+ T cells are associated with better clinical outcomes are also reviewed. Additionally, animal models in which protection was achieved without immunopathological consequences are discussed.

【 授权许可】

CC BY   
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