The importance of apoptosis for immune regulation in Chagas disease

Memórias do Instituto Oswaldo Cruz

George A Dosreis¹  Marcela F Lopes¹ 

[1] ,Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde Instituto de Biofísica Carlos Chagas FilhoRio de Janeiro RJ ,Brasil

关键词: apoptosis;    lymphocytes;    phagocytosis;    cytokines;    Trypanosoma cruzi;   

DOI  :  10.1590/S0074-02762009000900033

来源: SciELO

【 摘 要 】

Host cell apoptosis plays an important immune regulatory role in parasitic infections. Infection of mice with Trypanosoma cruzi, the causative agent of Chagas disease, induces lymphocyte apoptosis. In addition, phagocytosis of apoptotic cells stimulates the growth of T. cruzi inside host macrophages. In spite of progress made in this area, the importance of apoptosis in the pathogenesis of Chagas disease remains unclear. Here we review the evidence of apoptosis in mice and humans infected with T. cruzi. We also discuss the mechanisms by which apoptosis can influence underlying host responses and tissue damage during Chagas disease progression.

【 授权许可】

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