RFLP clusters of Mycobacterium tuberculosis strains from the Indian Ocean Region: local and South Asian characteristics

Memórias do Instituto Oswaldo Cruz

Voahangy Rasolofo Razanamparany²  Herimanana H Ramarokoto²  Elie J Vololonirina²  Tiana Rasolonavalona²  Alain Michault¹  Naidu Pyndiah¹  Rajbunsing Seenundun¹  Per Sandven¹  Suzanne Chanteau² 

[1] ,Institut Pasteur de Madagascar Unité des Mycobactéries Antananarivo,Madagascar

关键词: Mycobacterium tuberculosis;    IS6110 RFLP;    Indian Ocean Region;   

DOI  :  10.1590/S0074-02762009000300007

来源: SciELO

【 摘 要 】

This is the first study describing the genetic polymorphism of Mycobacterium tuberculosis strains in the Indian Ocean Region. Using IS6110 RFLP analysis, 475 M. tuberculosis isolates from Madagascar, Comoros, Mauritius, Mozambique and La Reunion were compared. Of the 332 IS6110 profiles found, 43 were shared by clusters containing 2-65 strains. Six clusters were common to at least two countries. Of 52 families of strains with similar IS6110 profiles, 10 were common to at least two countries. Interestingly, another characteristic was the frequency (16.8%) of IS6110 single-copy strains. These strains could be distinguished using the DR marker. This preliminary evaluation suggests genetic similarity between the strains of the Indian Ocean Region. However, additional markers would be useful for epidemiological studies and to assess the ancient transmission of strains between countries of this region.

【 授权许可】

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