Toxoplasma gondii infection induces lipid metabolism alterations in the murine host

Memórias do Instituto Oswaldo Cruz

Ivan Milovanović²  Marija Vujanić¹  Ivana Klun¹  Branko Bobić¹  Aleksandra Nikolić¹  Vladimir Ivović¹  Alexander M Trbovich²  Olgica Djurković-djaković¹ 

[1] ,University of Belgrade School of Medicine Institute of PathophysiologyBelgrade Serbia

关键词: toxoplasmosis;    murine infection;    lipid metabolism;    cholesterol;    adiponectin;   

DOI  :  10.1590/S0074-02762009000200008

来源: SciELO

【 摘 要 】

Host lipids have been implicated in the pathogenesis of Toxoplasma gondiiinfection. To determine if Toxoplasmainfection influences the lipid status in the normal host, we assessed serum lipids of Swiss-Webster mice during infection with the BGD-1 strain (type-2) at a series of time points. Mice were bled at days zero and 42 post-infection, and subgroups were additionally bled on alternating weeks (model 1), or sacrificed at days zero, 14 and 42 (model 2) for the measurement of total cholesterol (Chl), high density lipoproteins (HDL), low density lipoproteins (LDL) and triglycerides and adiponectin. At day 42, brains were harvested for cyst enumeration. A significant decrease (p = 0.02) in HDL and total Chl was first noted in infected vs. control mice at day 14 and persisted to day 42 (p = 0.013). Conversely, LDL was unaltered until day 42, when it increased (p = 0.043). Serum LDL levels at day 42 correlated only with cyst counts of above 300 (found in 44% mice), while the change in HDL between days zero and 42 correlated with both the overall mean cyst count (p = 0.041) and cyst counts above 300 (p = 0.044). Calculated per cyst, this decrease in HDL in individual animals ranged from 0.1-17 µmol/L, with a mean of 2.43 ± 4.14 µmol/L. Serum adiponectin levels remained similar between infected and control mice throughout the experiment.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License