Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate

Memórias do Instituto Oswaldo Cruz

Jadel Müller Kratz¹  Carla Regina Andrighetti-fröhner¹  Deise Juliana Kolling¹  Paulo César Leal¹  Cláudio César Cirne-santos¹  Rosendo Augusto Yunes¹  Ricardo José Nunes¹  Edward Trybala¹  Tomas Bergström¹  Izabel Cpp Frugulhetti¹  Célia Regina Monte Barardi¹  Cláudia Maria Oliveira Simões¹ 

关键词: antiviral;    HSV-1;    HIV-1;    gallic acid;    pentyl gallate;   

DOI  :  10.1590/S0074-02762008000500005

来源: SciELO

【 摘 要 】

The synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by food and pharmaceutical industries. The inhibitory effects of GA and 15 gallates on Herpes Simplex Virus type 1 (HSV-1) and Human Immunodeficiency Virus (HIV-1) replication were investigated here. After a preliminary screening of these compounds, GA and pentyl gallate (PG) seemed to be the most active compounds against HSV-1 replication and their mode of action was characterized through a set of assays, which attempted to localize the step of the viral multiplication cycle where impairment occurred. The detected anti-HSV-1 activity was mediated by the inhibition of virus attachment to and penetration into cells, and by virucidal properties. Furthermore, an anti-HIV-1 activity was also found, to different degrees. In summary, our results suggest that both compounds could be regarded as promising candidates for the development of topical anti-HSV-1 agents, and further studies concerning the anti-HIV-1 activity of this group of molecules are merited.

【 授权许可】

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