Prevalence, genotypes and risk factors associated with hepatitis C virus infection in hemodialysis patients in Campo Grande, MS, Brazil

Memórias do Instituto Oswaldo Cruz

Solange Z Freitas²  Rivaldo V Da Cunha²  Regina Mb Martins¹  Sheila A Teles¹  Mary L Ibanhes¹  Ana Rc Motta-castro² 

[1] ,Universidade Federal de Mato Grosso do Sul Departamento de Farmácia Bioquímica Campo Grande MS ,Brasil

关键词: hepatitis C virus;    hemodialysis;    prevalence;    genotypes;    risk factors;   

DOI  :  10.1590/S0074-02762008000400016

来源: SciELO

【 摘 要 】

A survey was conducted among the hemodialysis units of the city of Campo Grande, located in the state of Mato Grosso do Sul in the Mid-west region of Brazil, with the aim of investigating the prevalence, risk factors, and genotypes of hepatitis C virus (HCV) infection. A total of 163 patients were interviewed in five dialysis units. Serum samples were screened for anti-HCV. Positive samples were tested for HCV RNA and genotyped. The prevalence of anti-HCV was 11% (95% CI: 6.8-17.1). A history of transfusion with blood that was not screened for anti-HCV and length of time on hemodialysis were associated with HCV infection. HCV RNA was detected in 12 samples: ten were of genotype 1, subtypes 1a (75%) and 1b (8.3%), and two were of genotype 3, subtype 3a (16.7%).

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