Activity of Brazilian and Bulgarian propolis against different species of Leishmania

Memórias do Instituto Oswaldo Cruz

Gérzia Maria De Carvalho Machado²  Leonor Laura Leon²  Solange Lisboa De Castro¹ 

[1] ,Fiocruz Departamento de Imunologia Laboratório de Bioquímica de Tripanosomatídeos

关键词: Leishmania;    leishmaniasis;    propolis;    chemical composition;    natural products;   

DOI  :  10.1590/S0074-02762007000100012

来源: SciELO

【 摘 要 】

Extracts of propolis samples collected in Brazil and Bulgaria were assayed against four Leishmania species - Leishmania amazonensis, L. braziliensis, L. chagasi from the New World, and L. major from the Old World - associated to different clinical forms of leishmaniasis. The composition of the extracts has been previously characterized by high temperature high resolution gas chromatography coupled to mass spectrometry. Considering the chemical differences among the extracts and the behavior of the parasites, it was observed significant differences in the leishmanicidal activities with IC50/1 day values in the range of 2.8 to 229.3 µg/ml . An overall analysis showed that for all the species evaluated, Bulgarian extracts were more active than the ethanol Brazilian extract. As the assayed propolis extracts have their chemical composition determined it merits further investigation the effect of individual components or their combinations on each Leishmania species.

【 授权许可】

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