Human immunodeficiency virus type- 1 subtypes of infected patients in Espírito Santo, Brazil

Memórias do Instituto Oswaldo Cruz

Valéria P Cabral²  Carla B Cunha²  Eneida Fl Magalhaes²  Lauro F Pinto-neto¹  José Carlos Couto-fernandez¹  Reynaldo Dietze²  Mariza G Morgado¹  Rodrigo Ribeiro-rodrigues² 

[1] ,Universidade Federal do Espírito Santo Núcleo de Doenças Infecciosas Laboratório de Imunologia Celular e MolecularVitória ES ,Brasil

关键词: human immunodeficiency virus type 1 (HIV-1);    subtype;    Espírito Santo;    Brazil;   

DOI  :  10.1590/S0074-02762006000800010

来源: SciELO

【 摘 要 】

Genetic variability of human immunodeficiency virus type - 1(HIV-1) is a potential threat for both diagnosis and treatment of HIV/AIDS, as well as the development of effective vaccines. Up to now, HIV subtypes circulating among HIV-positive patients in the state of Espírito Santo were not known. In the present study, blood samples from 100 therapy-naïve HIV-1 infected patients were collected and the HIV subtype was determined through the Heteroduplex Mobility Assay (HMA). Ninety-seven out of 100 studied samples were subtyped by HMA, 73 samples (75.2%) were from subtype B, 9 (9.3%) from subtype F, 3 (3.1%) from subtype C, 6 (6.2%) Benv/Fgag, and another 6 (6.2%) Fenv/Bgag, what suggests that recombinant viruses were present in the studied samples. Twenty-eight percent of the subtype B samples were represented by the Brazilian B" subtype, which were identified by RFLP with Fok I. Data presented here demonstrate that the epidemiological characteristics of the HIV epidemic in the state of Espírito Santo are similar to those from the other Southeastern states and helped to better understand the genetic polymorphism of HIV in Brazil.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License