Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in São Paulo, Brazil

Memórias do Instituto Oswaldo Cruz

J Casseb²  Lmi Fukumori¹  Mpp Vergara²  S Sanabani¹  Pe Marchiori¹  Ajs Duarte¹  Acp De Oliveira² 

[1] ,Emílio Ribas Instituto de Infectologia Ambulatório de HTLVSão Paulo SP ,Brasil

关键词: human T-cell lymphotropic virus type 1;    tropical spastic paraparesis;    tax subtypes;    Brazil;   

DOI  :  10.1590/S0074-02762006000300008

来源: SciELO

【 摘 要 】

The product of human T-cell lymphotropic virus type 1 (HTLV-1) tax gene has a transactivating effect of the viral and cellular gene expression. Genetic variations in this gene have been correlated with differences in clinical outcomes. Based upon its diversity, two closely related substrains, namely tax A and tax B, have been described. The tax A substrain has been found at a higher frequency among human T-cell leukemia virus type 1 (TSP/HAM) patients than among healthy HTLV-I-infected asymptomatic subjects in Japan. In this study, we determined the distribution of tax substrains in HTLV-I-infected subjects in the city of São Paulo, Brazil. Using the ACCII restriction enzyme site, we detected only tax A substrain from 48 TSP/HAM patients and 28 healthy HTLV-I carriers. The sequenced tax genes from nine TSP/HAM patients and five asymptomatic HTLV-I carriers showed a similar pattern of mutation, which characterizes tax A. Our results indicate that HTLV-I tax subtypes have no significant influences on TSP/HAM disease progression. Furthermore, monophyletic introduction of HTLV-I to Brazil probably occurred during the African slave trade many years ago.

【 授权许可】

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